Amyloid deposition in all layers of the dermis is characteristic
of nodular amyloidosis. This is in contrast with the restriction of amyloid
deposition to the superficial dermis in macular amyloidosis
or in lichen amyloidosis. Although nodular amyloidosis may be limited to
the skin, the same type of pathology can be associated with primary systemic
amyloidosis, plasma cell dyscrasias, and paraproteinemias.
Scan power view. The pale lavender material in all
layers of the dermis is amyloid.
Superficial part of above.
High power of deeper part of biopsy. Note the perivascular
localization of the amyloid.
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