nipple duct adenomatosis

NIPPLE DUCT ADENOMATOSIS

This is also known as erosive adenomatosis of the nipple, nipple duct adenoma, and subareolar duct papillomatosis. The pathology can be the same as that which is seen in hidradenoma papilliferum of the pudendal region. Some of these resemble tubular adenomas of other sites.

Tubulopapillary structures are the essential elements of this lesion, and a surface connection is often demonstrated. The papillary structures may have connective tissue cores, or they may be composed of intraluminal cellular proliferations without connective tissue cores. Some tubules are lined by apocrine type epithelium, but the lining of most tubules is nondescript. The lining cells are often columnar, and myoepithelial cells may be seen at the periphery of some of the tubules. Pseudoinfiltrative patterns are disturbing when present.

Scan power view showing numerous tubulopapillary structures

Composite low power view showing epidermal connection and tubulopapillary structures.

High power showing a tubular structure with a peripheral row of myoepithelial cells (MEC).

High power showing a papillary structure with a connective tissue core.

Medium power view showing intraluminal papillary clusters of cells without connective tissue cores. This is a digitized television camera image, so it is not optimal.

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	High power showing a tubular structure with a peripheral row of myoepithelial cells (MEC).
	High power showing a papillary structure with a connective tissue core.
	Medium power view showing intraluminal papillary clusters of cells without connective tissue cores. This is a digitized television camera image, so it is not optimal.