GRANULAR CELL TUMOR HAVING PROMINENT FASCICLES
Fascicular components can often be found in granular cells tumors, but the solid components frequently dominate. The finding of aggregates of granules can be helpful in distinguishing between granular cells and foamy histiocytes. The original interpretation of these being of muscle origin (granular cell myoblastoma) has been abandoned. Neurotropic patterns and ultrastructural findings have led some to postulate neural or Schwann cell origin. Pseudoepitheliomatous epidermal hyperplasia of the type that is sometimes associated with granular cell tumors of mucosal locations is not a common feature of  cutaneous granular cell tumors. It should be noted that granular cell transformation can be seen in a variety of benign and malignant tumors.
Scan showing prominent fascicles or cords of tumor cells.
Low power of above.
High power of above. Arrows point to foci of condensation of cytoplasmic granules. This targetoid appearance has been interpreted as neurotropism or origin from neural type cells.
High power of a solid area showing progressive condensation of granules (1-3) with formation of clear zone around the most advanced.
Medium power showing infiltration or formation along a neurovascular bundle. Larger arrow points to nerve. Smaller arrow points to condensed granular material.
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