FOLLICULAR DIFFERENTIATION IN CHONDROID SYRINGOMAS

The apocrine gland is part of the embryologic pilosebaceous unit. Therefore, it is not surprising that follicular differentiation can occur in chondroid syringomas, at least some of which have apocrine features. It is actually more surprising that this combination of follicular and apocrine differentiation is not seen in more adnexal tumors or malformations.. One does see mixtures of these components in some examples of nevus sebaceous of  Jadassohn and in rare examples of sebaceous adenomas containing apocrine ducts. See also a case with prominent follicular differentiation.

 
 
Follicular differentiation in a chondroid syringoma, low power view.

 
High power view of above.

 
Follicular differentiation in a chondroid syringoma, low power.

 
High power view of above.

 
Follicular differentiation in a chondroid syringoma manifested by ghost cell formation of the type usually seen in pilomatrixomas, low power.

 
High power of above.

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