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Stroma that is chondroid or basophilic within the background of a benign tumor having sweat unit differentiation is the distinguishing feature of chondroid syringomas.

The diagnostic importance of the stroma cannot be overemphasized. Although true cartilage may be present, true cartilage is often absent. Of equal importance are:

pools of tissue mucin

variably cellular basophilic foci

variant wherein there are large, elongate, multilayered, or complex tubules

variant wherein there are pseudotubules, small relatively round tubules, or simple tubules.

entirely in the subcutis (commonly)

entirely in the dermis (rarely)

occupy both dermis and subcutis (commonly)

very well circumscribed

appear to be infiltrating

form well developed tubules or lumina, some of which may show apocrine differentiation

form intracytoplasmic lumina of eccrine type (rarely)

be nondescript

be found in fibroadenomatoid pattern
or have intraductal papillary pattern

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